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Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites

2009; Elsevier BV; Volume: 30; Issue: 23-24 Linguagem: Inglês

10.1016/j.biomaterials.2009.04.016

1878-5905

Keng Lin Wong, C. T. Wong, Wai‐Ching Liu, H.‐B. Pan, M.K. Fong, Wwm Lam, W.L. Cheung, Wing Man Tang, Pky Chiu, K.D.K. Luk, William W. Lu,

Facial Trauma and Fracture Management

Strontium-containing hydroxyapatite/polyetheretherketone (Sr-HA/PEEK) composites were developed as alternative materials for load-bearing orthopaedic applications. The amount of strontium-containing hydroxyapatite (Sr-HA) incorporated into polyetheretherketone (PEEK) polymer matrix ranged from 15 to 30 vol% and the composites were successfully fabricated by compression molding technique. This study presents the mechanical properties and in vitro human osteoblast-like cell (MG-63) response of the composite material developed. The bending modulus and strength of Sr-HA/PEEK composites were tailored to mimic human cortical bone. PEEK reinforced with 25 and 30 vol% Sr-HA exhibited bending modulus of 9.6 and 10.6 GPa, respectively; alternatively, the bending strengths of the composites were 93.8 and 89.1 MPa, respectively. Based on the qualitative comparison of apatite formation in SBF and quantitative measurement of MG-63-mediated mineralization in vitro, the Sr-HA/PEEK composite was proven to outperform HA/PEEK in providing bioactivity. However, no difference was found in the trend of cell proliferation and alkaline phosphatase activity between different composites. Strontium, in the form of strontium-containing hydroxyapatite (Sr-HA), was confirmed to enhance bioactivity in the PEEK composites.