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Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE)

1999; Wiley; Volume: 13; Issue: 7 Linguagem: Inglês

10.1002/(sici)1099-1573(199911)13

1099-1573

Krishnaveni Vedavanam, Sairavee Srijayanta, James O’Reilly, Amala Raman, Helen Wiseman,

Estrogen and related hormone effects

Phytotherapy ResearchVolume 13, Issue 7 p. 601-608 Research Article Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE) Krishnaveni Vedavanam, Krishnaveni Vedavanam Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorSairavee Srijayanta, Sairavee Srijayanta Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorJames O’Reilly, James O’Reilly Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorAmala Raman, Amala Raman Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorHelen Wiseman, Corresponding Author Helen Wiseman Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKDepartment of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this author Krishnaveni Vedavanam, Krishnaveni Vedavanam Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorSairavee Srijayanta, Sairavee Srijayanta Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorJames O’Reilly, James O’Reilly Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorAmala Raman, Amala Raman Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this authorHelen Wiseman, Corresponding Author Helen Wiseman Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKDepartment of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 8WA, UKSearch for more papers by this author First published: 03 November 1999 https://doi.org/10.1002/(SICI)1099-1573(199911)13:7 3.0.CO;2-OCitations: 120AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The potential role of oestrogenic agents, antioxidants and intestinal glucose-uptake inhibitors in the treatment of diabetes is briefly reviewed. Reports in the literature suggest that oestrogen replacement therapy may favourably modulate glucose homeostasis. A soya phytochemical extract (SPE) containing the isoflavone phytoestrogens genistein and daidzein (mostly in their glycone forms as genistin and daidzin) was investigated as an antioxidant and modulator of intestinal glucose-transport. In the present study, SPE was found to protect against glucose-induced oxidation of human low density lipoproteins (LDL) in vitro. Equol (a gut bacterial metabolite of daidzein) was a more effective antioxidant than daidzein or genistein in this system and was of similar antioxidant potency to the dietary flavonols quercetin and kaempferol and to the endogenous antioxidant 17β-oestradiol. SPE was found to be an inhibitor of glucose uptake into rabbit intestinal brush border membrane vesicles in vitro, though of weaker potency than the classical sodium dependent glucose transporter (SGLT) inhibitor, phlorizin. Thus SPE displays a range of properties which may be of benefit in diabetes, namely as an oestrogenic agent, an inhibitor of intestinal glucose-uptake and a preventive agent for glucose-induced lipid peroxidation. Copyright © 1999 John Wiley & Sons, Ltd. Citing Literature Volume13, Issue7November 1999Pages 601-608 RelatedInformation