Higher viral load may explain the dominance of CRF02_AG in the molecular epidemiology of HIV in Ghana
2004; Lippincott Williams & Wilkins; Volume: 18; Issue: 8 Linguagem: Inglês
10.1097/00002030-200405210-00017
ISSN1473-5571
AutoresLucia Fischetti, Ohene Opare‐Sem, Daniel Candotti, Helen Lee, Jean‐Pierre Allain,
Tópico(s)HIV/AIDS Research and Interventions
ResumoPhylogenetic analysis of Ghanaian plasma samples from 84 asymptomatic candidate blood donors and 150 AIDS patients revealed a 63% prevalence of HIV-1 CRF02_AG. HIV-1 viral load in both populations was quantified using real-time reverse transcriptase-polymerase chain reaction. In asymptomatic candidate blood donors infected with CRF02_AG, the viral load was significantly higher than in donors infected with other HIV-1 molecular forms. A higher viral load of CRF02-AG is compatible with higher infectivity and prevalence.
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