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COMPARISON OF α1-ADRENOCEPTOR AGONISTS IN CANINE URETHRAL PRESSURE PROFILOMETRY AND ABDOMINAL LEAK POINT PRESSURE MODELS

2001; Lippincott Williams & Wilkins; Volume: 166; Issue: 4 Linguagem: Inglês

10.1016/s0022-5347(05)65829-6

1527-3792

Michael E. Brune, Alyssa B. O'Neill, Donna M. Gauvin, Sweta P. Katwala, Robert J. Altenbach, Jorge D. Brioni, Arthur A. Hancock, James P. Sullivan,

Veterinary Medicine and Surgery

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Oct 2001COMPARISON OF α1-ADRENOCEPTOR AGONISTS IN CANINE URETHRAL PRESSURE PROFILOMETRY AND ABDOMINAL LEAK POINT PRESSURE MODELS MICHAEL E. BRUNE, ALYSSA B. O'NEILL, DONNA M. GAUVIN, SWETA P. KATWALA, ROBERT J. ALTENBACH, JORGE D. BRIONI, ARTHUR A. HANCOCK, and JAMES P. SULLIVAN MICHAEL E. BRUNEMICHAEL E. BRUNE , ALYSSA B. O'NEILLALYSSA B. O'NEILL , DONNA M. GAUVINDONNA M. GAUVIN , SWETA P. KATWALASWETA P. KATWALA , ROBERT J. ALTENBACHROBERT J. ALTENBACH , JORGE D. BRIONIJORGE D. BRIONI , ARTHUR A. HANCOCKARTHUR A. HANCOCK , and JAMES P. SULLIVANJAMES P. SULLIVAN View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65829-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We describe and compare the usefulness of 3 minimally invasive dog urethral function models to demonstrate the efficacy potential of α1 agonists for stress urinary incontinence. From this overall composite dataset the efficacy profiles of the α1A selective agonist A-61603 and the active metabolite of midodrine ST-1059 were specifically compared. Materials and Methods: Isoflurane anesthetized multiparous female beagle dogs were used in all studies. Intraurethral pressure was measured using a 7Fr balloon catheter. Profilometry was performed using an 8Fr Millar transducer catheter. Bladder pressure required to produce leakage in response to external abdominal ballottements of increasing intensity was measured using a 5Fr transurethral catheter. Agonist responses were measured before and after increasing cumulative intravenous doses of each compound in each test. Results: Agonist induced increases in maximal urethral closure and leak point pressure strongly correlated in linear fashion (R2 = 0.94), as did measurements of agonist induced increases in proximal intraurethral pressure using the microtransducer or balloon catheter technique (R2 = 0.87). A dose of 0.01 to 1 nmol./kg. A-61603 and 10 to 1,000 nmol./kg. ST-1059 intravenously each caused dose dependent increases in maximum urethral closure, leak point and intraurethral pressure. Conclusions: While the dose range for which α1 agonists affect urethral pressure was adequately predicted by any of the 3 methods used, the leak point pressure assay described has the advantage of being a dynamic test that directly evaluates efficacy to protect against leakage caused by increases in abdominal pressure. 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Volume 166 Issue 4 October 2001 Page: 1555-1559 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsbladderdogsurethramuscle, smoothreceptors, adrenergic, alpha-1Metrics Author Information MICHAEL E. BRUNE More articles by this author ALYSSA B. O'NEILL More articles by this author DONNA M. GAUVIN More articles by this author SWETA P. KATWALA More articles by this author ROBERT J. ALTENBACH More articles by this author JORGE D. BRIONI More articles by this author ARTHUR A. HANCOCK More articles by this author JAMES P. SULLIVAN More articles by this author Expand All Advertisement PDF downloadLoading ...