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A new cytotoxic casbane diterpene from Euphorbia pekinensis

2009; Elsevier BV; Volume: 80; Issue: 8 Linguagem: Inglês

10.1016/j.fitote.2009.06.014

1873-6971

Qiaoli Liang, Chuan‐Chao Dai, Jihong Jiang, Yuping Tang, Jin‐Ao Duan,

Plant-based Medicinal Research

A new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of Euphorbia pekinensis. Its structure was elucidated as 5α-hydroxy-1βH,2αH-casba-3Z,7E,11E-triene-18-al by a combination of 1D- and 2D-NMR techniques and confirmed by X-ray crystallography. Pekinenal showed cytotoxic activity against all four human cancer cell lines tested.