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Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience

2007; Lippincott Williams & Wilkins; Volume: 21; Issue: 18 Linguagem: Inglês

10.1097/qad.0b013e328273bc07

1473-5571

Laura Waters, Sundhiya Mandalia, Brian Gazzard, Mark Nelson,

Contact Dermatitis and Allergies

Suspected hypersensitivity is the main reason for the early discontinuation of abacavir. After the observation that the risk of hypersensitivity correlated with ethnicity, the presence of the HLA allele B*5701 was found to be the strongest retrospective predictor of hypersensitivity. Two prospective cohorts have since demonstrated a significant reduction in abacavir hypersensitivity rates with the use of prospective human leukocyte antigen screening. We describe our experience of prospective HLA-B*5701 testing and the impact on rates of abacavir hypersensitivity.