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Preliminary in vitro evaluation of N′-(benzofuroxan-5-yl)methylene benzohydrazide derivatives as potential anti-Trypanosoma cruzi agents

2012; Royal Society of Chemistry; Volume: 3; Issue: 7 Linguagem: Inglês

10.1039/c2md20019h

2040-2511

Salomão Dória Jorge, Marina Ishii, Fanny Palace‐Berl, Adilson Kleber Ferreira, Paulo Luiz de Sá Júnior, Alex Alfredo de Oliveira, Ieda Yuriko Sonehara, Kerly Fernanda Mesquita Pasqualoto, Leoberto Costa Tavares,

Fungal Plant Pathogen Control

A set of benzofuroxan derivatives was tested in vitro against Trypanosoma cruzi epimastigote forms. The influence of physicochemical properties on these benzofuroxan derivatives' activity was observed, and the presence of electron-withdrawing and hydrophobic groups attached to the benzene ring seems to make a favorable contribution at lower concentrations.