Chemoenzymatic synthesis of the C-13 side chain of paclitaxel (Taxol) and docetaxel (Taxotere)
2000; Elsevier BV; Volume: 11; Issue: 22 Linguagem: Inglês
10.1016/s0957-4166(00)00418-3
ISSN1362-511X
AutoresHiromi Hamamoto, В. А. Мамедов, Makiko Kitamoto, Nobuyuki Hayashi, Sadao Tsuboi,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoAbstract Reduction of methyl 3-chloro-2-oxo-3-phenylpropanoate with various reducing agents gave syn - and anti -3-chloro-2-hydroxy-3-phenylpropanoates 3 , which underwent an efficient lipase-catalyzed resolution. All four diastereomers were subsequently converted to N -benzoyl-(2 R ,3 S )-3-phenylisoserine methyl ester, C-13 side chain analogues of paclitaxel (Taxol).
Referência(s)