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Altered PI3-Kinase/Akt Signalling in Skeletal Muscle of Young Men with Low Birth Weight

2008; Public Library of Science; Volume: 3; Issue: 11 Linguagem: Inglês

10.1371/journal.pone.0003738

1932-6203

Christine B. Jensen, Malgorzata S. Martin‐Gronert, Heidi Storgaard, Sten Madsbad, Allan Vaag, Susan E. Ozanne,

Pancreatic function and diabetes

Low birth weight (LBW) is associated with increased future risk of insulin resistance and type 2 diabetes mellitus. The underlying molecular mechanisms remain poorly understood. We have previously shown that young LBW men have reduced skeletal muscle expression of PI3K p85alpha regulatory subunit and p110beta catalytic subunit, PKCzeta and GLUT4 in the fasting state. The aim of this study was to determine whether insulin activation of the PI3K/Akt and MAPK signalling pathways is altered in skeletal muscle of young adult men with LBW.