Produção Nacional
Terapia celular da pseudoartose
2012; Brazilian Society of Orthopedics and Traumatology; Volume: 20; Issue: 5 Linguagem: Inglês
10.1590/s1413-78522012000500005
ISSN2176-7521
AutoresRicardo Bastos, Simone Pereira Lermontov, Radovan Borojević, Paulo Cezar de Malta Schott, Vinícius Schott Gameiro, José Mauro Granjeiro,
Tópico(s)Hip disorders and treatments
ResumoTo assess the safety and efficiency of cell therapy for pseudarthrosis. Implant of the bone marrow aspirate was compared to mononuclear cells purified extemporaneously using the Sepax(®) equipment.Six patients with nonunion of the tibia or femur were treated. Four received a percutaneous infusion of autologous bone marrow aspirated from the iliac crest, and two received autologous bone marrow mononuclear cells separated from the aspirate with the Sepax(®). The primary fixation method was unchanged, and the nonunion focus was not exposed. Physical examination and radiographies were performed 2, 4 and 6 months after the treatment by the same physician. After consolidation of the fracture the satisfaction of the patients was estimated using the adapted QALY scale.No complications occurred as a result of the referred procedures. Bone consolidation was obtained in all cases within 3 to 24 weeks. The degree of patient satisfaction before and after bone consolidation was assessed, with the average value increasing from two to nine (p=0.0156).We conclude that the proposed method is effective and safe for the treatment of nonunion of long bones regardless of the stabilization method used. Level of Evidence II, Prospective Comparative Study.
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