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Stereocontrolled synthesis of 2,3-diaminobutanoic acids

1997; Elsevier BV; Volume: 38; Issue: 10 Linguagem: Inglês

10.1016/s0040-4039(97)00158-5

1873-3581

Pedro Merino, A. Lanaspa, F. L. MERCHAN, Tomás Tejero,

Asymmetric Synthesis and Catalysis

A straightforward synthesis of 2,3-diaminobutanoic acids is reported. The synthesis is based on the nucleophilic addition of methylmagnesium bromide to differentially protected nitrones derived from l-serine. The change of the protecting groups in the starting nitrone is crucial for the stereocontrol of the reaction.