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Long-range DNA contacts: romance in the nucleus?

2007; Elsevier BV; Volume: 19; Issue: 3 Linguagem: Inglês

10.1016/j.ceb.2007.04.004

1879-0410

Wouter de Laat,

RNA and protein synthesis mechanisms

Recent studies show that genes far apart on the same chromosome or even on different chromosomes can come together in the nuclear space. It has been hypothesized that functionally related genes 'kiss' at transcription factories to coordinate their expression. Novel high-throughput methods, such as 4C technology, that study DNA interactions in an unbiased manner should uncover the generality of this romantic concept of nuclear architecture.