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Quantitative Analysis of a Urine-Based Assay for Detection of Lipoarabinomannan in Patients with Tuberculosis

2010; American Society for Microbiology; Volume: 48; Issue: 8 Linguagem: Inglês

10.1128/jcm.00363-10

1098-660X

Maunank Shah, Neil Martinson, Richard E. Chaisson, Desmond J. Martin, Ebrahim Variava, Susan E. Dorman,

Pneumocystis jirovecii pneumonia detection and treatment

ABSTRACT Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.