Portal de Periódicos da CAPES

Tailoring of Bioresorbable Polymers for Elaboration of Sugar-Functionalized Nanoparticles

2004; American Chemical Society; Volume: 5; Issue: 3 Linguagem: Inglês

10.1021/bm034504b

1526-4602

David Cade, Elsa Ramus, Marguerite Rinaudo, Rachel Auzély‐Velty, Thierry Delair, Thierry Hamaide,

Glycosylation and Glycoproteins Research

Maleic copolymers with different contents of galactose moieties and dodecyl chains were synthesized and used as both a stabilizer and a surface coating for the preparation of poly(ε-caprolactone) nanoparticles by the emulsification−diffusion technique. The size of the nanoparticles was controlled by varying the initial concentration of the modified maleic copolymers. As the concentration of the latter increased, the particle size decreased, indicating that the copolymers serve as a stabilizer. Moreover, surface modification of nanoparticles was confirmed by ξ-potential measurements. Nanoparticles were also shown to be recognized by a galactose-specific lectin, demonstrating the presence of galactose units on the particle surface. This approach offers opportunities for the production of novel targeted drug delivery systems.