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Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

2015; National Academy of Sciences; Volume: 112; Issue: 12 Linguagem: Inglês

10.1073/pnas.1502585112

1091-6490

Chad J. Roy, Robert N. Brey, Nicholas J. Mantis, Kelly Mapes, Iliodora V. Pop, Laurentiu M. Pop, Stephen Ruback, Stephanie Z. Killeen, Lara Doyle‐Meyers, Heather Vinet-Oliphant, Peter J. Didier, Ellen S. Vitetta,

Plant Virus Research Studies

Significance Ricin toxin (RT) is a CDC-designated select agent that can be dispersed as an aerosol. In mammals, aerosolized RT causes rapid and irreversible necrosis of the lung epithelium, multifocal hemorrhagic edema, and death within 24–36 h. A safe and effective recombinant subunit vaccine (RiVax) has been developed and formulated as a thermostable, lyophilized, adjuvant-containing “powder.” This formulation of RiVax elicited neutralizing antibodies against RT, which protected macaques from the lethality of aerosolized RT. The epitope-specific antibody responses in macaques revealed a distinctive profile that was also observed in vaccinated humans. This profile might represent a signature of protection in both species.