Solitary Primary Cutaneous CD30+ Large Cell Lymphoma of Natural Killer Cell Phenotype Bearing the t(2;5)(p23;q35) Translocation and Presenting in a Child
2000; Lippincott Williams & Wilkins; Volume: 22; Issue: 5 Linguagem: Inglês
10.1097/00000372-200010000-00007
ISSN1533-0311
AutoresJennifer W. Gould, R Bennett Eppes, Anita C. Gilliam, Jeffrey A. Goldstein, Debra Mikkola, M. Zaim, Gary S. Wood,
Tópico(s)CNS Lymphoma Diagnosis and Treatment
ResumoPrimary cutaneous CD30+ large cell lymphoma is an unusual tumor most commonly seen in adults. Most of these lymphomas are of T-cell origin and carry a good prognosis. We present the case of a 4-year-old girl with stage IEA CD30+ large cell lymphoma with a CD56+ natural killer cell phenotype and the t(2;5)(p23;q35) translocation. After excision, the patient has been free of disease for 44 months. Primary cutaneous CD30+ large cell lymphoma is uncommon in children. To our knowledge, primary cutaneous CD30+ natural killer type lymphoma has not been reported previously. The indolent behavior of this tumor indicates its similarity to other primary cutaneous CD30+ large cell lymphomas and its difference from other CD56+ lymphomas involving the skin, which often exhibit an aggressive clinical course. Cases such as this one illustrate why the use of a single, or even a few, immunohistochemical stains can be misleading in regard to lymphoma classification and prognostication.
Referência(s)