Portal de Periódicos da CAPES

Revisão Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Snake Venom L-Amino Acid Oxidases: Trends in Pharmacology and Biochemistry

2014; Hindawi Publishing Corporation; Volume: 2014; Linguagem: Inglês

10.1155/2014/196754

2314-6141

Luíz Fernando Moreira Izidoro, Juliana C. Sobrinho, Mirian Machado Mendes, Tássia R. Costa, Amy N. Grabner, Veridiana de Melo Rodrigues, Saulo L. da Silva, Fernando Berton Zanchi, Juliana P. Zuliani, Carla Freire Celedônio Fernandes, Leonardo A. Calderón, Rodrigo G. Stábeli, Andreimar M. Soares,

Marine Invertebrate Physiology and Ecology

L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.