Mutagenicity of ptaquiloside, the carcinogen in bracken, and its related illudane-type sesquiterpenes I. Mutagenicity in Salmonella typhimurium
1989; Elsevier BV; Volume: 215; Issue: 2 Linguagem: Inglês
10.1016/0027-5107(89)90181-4
ISSN1873-135X
AutoresTakayuki Nagao, Kimiaki Saitô, Emiko Hirayama, Kumi Uchikoshi, Kiyotaka Koyama, Shinsaku Natori, Naoko Morisaki, Shigeo Iwasaki, T. Matsushima,
Tópico(s)Pesticide Exposure and Toxicity
ResumoPtaquiloside, a potent carcinogen of an illudane-type sesquiterpene glycoside isolated from Pteridium aquilinum, and its related compounds, hypolosides having the same nucleus isolated from the Pteridaceae, exhibited marked mutagenicity in the modified Ames test with Salmonella typhimurium TA98 and TA100 using a preincubation at pH 8.5. Illudins M and S, sesquiterpenes of the same illudane type from basidiomycetes, also exhibited mutagenicity. The structural requirements for mutagenicity are discussed.
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