Selective modification of uridine and guanosine residues in tyrosine transfer ribonucleic acid
1972; Elsevier BV; Volume: 68; Issue: 3 Linguagem: Inglês
10.1016/0022-2836(72)90099-x
ISSN1089-8638
AutoresSidney E. Chang, Anthony R. Cashmore, D. M. Brown,
Tópico(s)RNA modifications and cancer
ResumoThe specificity of 1-cyclohexyl 3-[2-morpholino(4)-ethyl] carbodiimide methotosylate for the uridine and guanosine residues in Escherichia coli suppressor tyrosine transfer RNA is described in detail. The positions of the reactive residues, G15, U34, U36, U47, U50, G66 and U69, are discussed in terms of transfer RNA conformation. An attempt is made to relate loss in tyrosine acceptor activity with the extent and position of modification.
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