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Anaphylactic reactions to Hymenoptera stings in asthmatic patients*

1980; Wiley; Volume: 10; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2222.1980.tb02149.x

1365-2222

Guy A. Settipane, Francis H. Chafee, Donald E. Klein, George K. Boyd, J. H. STURAM, Henry B. Freye,

Food Allergy and Anaphylaxis Research

Summary We evaluated 587 cases with generalized reactions to stings of Hymenoptera. Eighty of these patients and twenty‐eight normal controls had radioallergosorbent tests (RAST) to venoms of honey bee, yellow jacket, hornet, wasp and to phospholipase A. Those patients with systemic reactions had a significantly greater frequency of positive RAST than normal controls (51.3% vs. 7.1%, P < 0.001). The frequency of atopy (asthma/rhinitis) in these 587 cases was only 22% and resembled the expected frequency in a general population. Asthmatic patients did not have an increased risk of developing systemic reactions to Hymenoptera stings. However, those asthmatic patients with systemic reactions to Hymenoptera stings had a significantly more severe anaphylactic reaction to a sting than non‐asthmatics. These severe reactions were primarily manifested by acute dyspnoea, which appeared to represent a bronchospastic response to endogenous histamine release.