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CD30-mediated signaling promotes the development of human T helper type 2-like T cells.

1995; Rockefeller University Press; Volume: 182; Issue: 6 Linguagem: Inglês

10.1084/jem.182.6.1655

1540-9538

Gianfranco Del Prete, Marco Carli, Mario Milco D’Elios, Kenn Curt Daniel, Fabio Almerigogna, Mark R. Alderson, Craig A. Smith, Evan P. Thomas, Sergio Romagnani,

Immunotherapy and Immune Responses

We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag-specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.