Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Optimisation of a continuous flash fermentation for butanol production using the response surface methodology

2009; Elsevier BV; Volume: 88; Issue: 5-6 Linguagem: Inglês

10.1016/j.cherd.2009.11.002

1876-4800

Adriano Pinto Mariano, Caliane Bastos Borba Costa, Dejanira de Franceschi de Angelis, Francisco Maugeri Filho, Daniel Ibraim Pires Atala, Maria Regina Wolf Maciel, Rubens Maciel Filho,

Optimal Experimental Design Methods

Factorial design and response surface techniques were used in combination with mathematical modelling and computational simulation to optimise an innovative industrial bioprocess, the production of biobutanol employing the flash fermentation technology. A parametric analysis performed by means of a full factorial design at two levels determined the influence of operating variables on butanol yield and productivity. A second set of simulations were carried out based on the central composite rotatable design. This procedure generated simplified statistical models that describe butanol yield and productivity as functions of the significant operating variables. From these models, response surfaces were obtained and used to optimise the process. For a range of substrate concentration from 130 to 180 g/l, the optimum operating ranges ensure butanol productivity between 7.0 and 8.0 g/l h, butanol yield between 19 and 22%, substrate conversion above 90% and final butanol concentration around 25 g/l.