Produção Nacional
Revisado por pares
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis
2010; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês
10.1016/s1413-8670(10)70071-4
ISSN1678-4391
AutoresRenata Eliane de Ávila, Ricardo Andrade Carmo, Kátia de Paula Farah, Antônio Lúcio Teixeira, Lucas Viana Coimbra, Carlos Maurício de Figueiredo Antunes, José Roberto Lambertucci,
Tópico(s)Liver Disease and Transplantation
ResumoThis study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR ≥ F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.
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