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A Novel Respiratory Model of Infection with Monkeypox Virus in Cynomolgus Macaques

2011; American Society for Microbiology; Volume: 85; Issue: 10 Linguagem: Inglês

10.1128/jvi.02525-10

1098-5514

Arthur J. Goff, Jennifer L. Chapman, Chad Foster, Carly Wlazlowski, Joshua D. Shamblin, Kenny Lin, Norman Kreiselmeier, Eric M. Mucker, Jason Paragas, James V. Lawler, Lisa E. Hensley,

Bacillus and Francisella bacterial research

ABSTRACT Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in “classic” orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.