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Total synthesis of (10ξ,15R,16S,19S,20S,34R)-Corossoline

1994; Elsevier BV; Volume: 35; Issue: 1 Linguagem: Inglês

10.1016/0040-4039(94)88189-8

1873-3581

Zhu‐Jun Yao, Yu‐Lin Wu,

Phytochemical compounds biological activities

(10ξ, 15R, 16S, 19S,20S,34R)-Corossoline, a structural representative of the cytotoxic monotetrahydrofuranyl annonaceous acetogenins, was synthesized from two chiral starting materials -- (S)-glutamic acid and (R)-ethyl lactate, and 10-undecenoic acid.