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Production of oxytetracycline and rifamycins B and SV with cells immobilized on glass wool

1994; Wiley; Volume: 14; Issue: 1 Linguagem: Inglês

10.1002/abio.370140112

1521-3846

Mohamed A. Farid, Ahmed I. El‐Diwany, Hesham Ali El Enshasy,

Microbial Metabolism and Applications

Abstract The antibiotic producing microorganisms Streptomyces rimosus PFIZER 18234‐2 and Amycolatopsis mediterranei CBS 42575 were immobilized in glass wool for the production of oxytetracycline and rifamycins B and SV. The growth of the immobilized cells was dependent on the type of the microorganism and on the amount of glass wool as well. After 5 exchanges of the medium, 530 mg O.T.C., 2138 mg rifamycin B and 8672 mg rifamycin SV were maintained. The periodic batch culture was continued for 20 days.