Portal de Periódicos da CAPES

Comparing two dinoprostone agents for cervical ripening and induction of labor: A randomized trial

2007; Elsevier BV; Volume: 138; Issue: 2 Linguagem: Inglês

10.1016/j.ejogrb.2007.08.009

1872-7654

Anna Maria Marconi, Patrizia Bozzetti, Alberto Morabito, Giorgio Pardi,

Maternal and fetal healthcare

Objective To compare dinoprostone gel and insert in achieving successful vaginal delivery in nulliparous and multiparous women. Study design 220 nulliparous and 100 multiparous with a Bishop score ≤7 were randomized to receive dinoprostone either gel or insert for cervical ripening. The main outcome measures were the rate and latency of vaginal delivery. Results In nulliparous women no significant differences were found between the gel and insert groups in the rate of vaginal delivery (85.6% vs. 80.7%) delivery ≤12 (36.8% vs. 32.9%) and ≤24 h (85.3% vs. 93.4%) regardless of the preinduction Bishop score. Nulliparous with Bishop score ≤4 treated with the insert had a decreased risk (p < 0.05) of post partum hemorrhage (4.8%) when compared with nulliparous treated with gel (16.7%). On the contrary, in multiparous the time to delivery interval was significantly shorter in the gel treated group (9.9 ± 4.9 h vs. 13.1 ± 5 h; p < 0.001) with more patients delivering vaginally ≤12 h (75% vs. 37.5%, p < 0.001), regardless of the preinduction Bishop score. Conclusion Both dinoprostone gel and insert are efficient in achieving cervical ripening and successful labor in nulliparous and multiparous. In multiparous, however, the gel significantly reduces the time to vaginal delivery with more patients delivering vaginally ≤12 h, regardless of the Bishop score.