Excitatory and inhibitory action of dopamine on hippocampal neurons in vitro. Involvement of D2 and D1 receptors
1987; Elsevier BV; Volume: 23; Issue: 1 Linguagem: Inglês
10.1016/0306-4522(87)90274-0
ISSN1873-7544
Autores Tópico(s)Neuropeptides and Animal Physiology
ResumoThe study examined the effects of dopaminergic agonists on the extracellularly recorded spontaneous activity of CAl neurons in hippocampal slices of the rat. Dopamine evoked excitation or inhibition of the neuronal firing rate, the first reaction being more sensitive to the substance. Having used selective dopaminergic agonists (pergolide and 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepines) and selective antagonists (haloperidol, spiperone,sulpiride and (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol), it was concluded that the excitation evoked by dopamine was due to activation of D2 dopamine receptors, while the inhibition was the result of D1 receptor activation. The effects of the dopamine agonists on the firing of CAl neurons were long-lasting, which suggests a modulating role of dopamine in the hippocampus.
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