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Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c

2012; Oxford University Press; Volume: 152; Issue: 5 Linguagem: Inglês

10.1093/jb/mvs085

1756-2651

Kohei Takeshita, Tohru Tezuka, Y. Isozaki, Eiki Yamashita, Mamoru Suzuki, Minsoo Kim, Yuji Yamanashi, Tadashi Yamamoto, Atsushi Nakagawa,

Protein Kinase Regulation and GTPase Signaling

Journal Article Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c Get access Kohei Takeshita, Kohei Takeshita 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Tohru Tezuka, Tohru Tezuka † 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639;4Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan †Corresponding author: Tohru Tezuka, Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 6409 2118, Fax: +81 3 6409 2116, email: ttezuka@ims.u-tokyo.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Yukari Isozaki, Yukari Isozaki 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Eiki Yamashita, Eiki Yamashita 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Mamoru Suzuki, Mamoru Suzuki 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Minsoo Kim, Minsoo Kim 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuji Yamanashi, Yuji Yamanashi 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Tadashi Yamamoto, Tadashi Yamamoto 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; Search for other works by this author on: Oxford Academic PubMed Google Scholar Atsushi Nakagawa Atsushi Nakagawa ‡ 1Institute for Protein Research, Osaka University, Suita, Osaka 565-0871; 2Division of Oncology; 3Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; †Corresponding author: Tohru Tezuka, Division of Genetics, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. Tel: +81 3 6409 2118, Fax: +81 3 6409 2116, email: ttezuka@ims.u-tokyo.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 152, Issue 5, November 2012, Pages 487–495, https://doi.org/10.1093/jb/mvs085 Published: 09 August 2012 Article history Received: 06 July 2012 Accepted: 24 July 2012 Published: 09 August 2012