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Lack of Association between Hypermutation and Antibiotic Resistance Development in Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients

2004; American Society for Microbiology; Volume: 48; Issue: 9 Linguagem: Inglês

10.1128/aac.48.9.3573-3575.2004

1098-6596

Olivia Gutiérrez, Carlos Juan, José Luis Pérez, Antonio Oliver,

Bacterial biofilms and quorum sensing

Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational antibiotic resistance development is a frequent outcome, the prevalence of hypermutable strains is low (found in isolates from only 1 of 103 patients) and there is no evidence of coselection of the hypermutable and antibiotic resistance phenotypes.