F VIII:CAg in haemophilia A a comparison between IRMA:s using haemophilic and spontaneous antibodies
1981; Elsevier BV; Volume: 24; Issue: 1-2 Linguagem: Inglês
10.1016/0049-3848(81)90030-x
ISSN1879-2472
Autores Tópico(s)Blood Coagulation and Thrombosis Mechanisms
ResumoFactor VIII clotting antigen (VIII:CAg) was measured with two different immunoradiometric assays, one utilizing two acquired antibodies and one a haemophilic antibody, in order to investigate the genetic heterogeneity in haemophilia A of different severity and to what extent VIII:CAg levels depends on the antibody used. Fifteen severe haemophiliacs were, with one exception, classified as CRM-.Eleven moderate and 21 mild haemophiliacs were investigated and there was a good agreement between the results obtained with the different antibodies. The study confirms the division of both moderate and mild haemophilia A into 3 subgroups, proposed in an earlier investigation. It also favours the opinion that in haemophilia A there is a quantitative reduction rather than a qualitative defect in the protein responsible for factor VIII clotting activity (VIII:C).
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