Portal de Periódicos da CAPES

Sizing and shaping the nucleus: mechanisms and significance

2014; Elsevier BV; Volume: 28; Linguagem: Inglês

10.1016/j.ceb.2014.01.003

1879-0410

Predrag Jevtić, Lisa J. Edens, Lidija Vuković, Daniel L. Levy,

Microtubule and mitosis dynamics

The size and shape of the nucleus are tightly regulated, indicating the physiological significance of proper nuclear morphology, yet the mechanisms and functions of nuclear size and shape regulation remain poorly understood. Correlations between altered nuclear morphology and certain disease states have long been observed, most notably many cancers are diagnosed and staged based on graded increases in nuclear size. Here we review recent studies investigating the mechanisms regulating nuclear size and shape, how mitotic events influence nuclear morphology, and the role of nuclear size and shape in subnuclear chromatin organization and cancer progression.