Portal de Periódicos da CAPES

The immune contexture of primary and metastatic human tumours

2014; Elsevier BV; Volume: 27; Linguagem: Inglês

10.1016/j.coi.2014.01.001

1879-0372

Nicolás A. Giraldo, Étienne Becht, Romain Remark, Diane Damotte, Catherine Sautès‐Fridman, Wolf H. Fridman,

Immune Cell Function and Interaction

A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates with a longer survival. This beneficial effect can be hampered by the presence of M2 polarized macrophages and high VEGF production. Recent studies revealed that the pattern of the tumour microenvironment remains a major prognostic factor even in the metastatic lesions, while been reproducible between the primary and metastatic tumour. Nevertheless the prognostic impact of the Th1/cytotoxic T cell infiltrate could be different according to the origin of the primary tumour. This model highlights a novel tumour cell-dependent immune contexture that predicts patient's clinical outcome and has implications in the use of immunotherapies.