Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds
2012; Elsevier BV; Volume: 162; Issue: 4 Linguagem: Inglês
10.1016/j.jbiotec.2012.03.023
ISSN1873-4863
AutoresChristoph K. Winkler, Gábor Tasnádi, Dorina Clay, Mélanie Hall, Kurt Faber,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoEne-reductases from the 'Old Yellow Enzyme' family of flavoproteins catalyze the asymmetric reduction of various α,β-unsaturated compounds at the expense of a nicotinamide cofactor. They have been applied to the synthesis of valuable enantiopure products, including chiral building blocks with broad industrial applications, terpenoids, amino acid derivatives and fragrances. The combination of these highly stereoselective biocatalysts with a cofactor recycling system has allowed the development of cost-effective methods for the generation of optically active molecules, which is strengthened by the availability of stereo-complementary enzyme homologues.
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