Portal de Periódicos da CAPES

Nutrient, Neural and Endocrine Control of Glucagon-like Peptide Secretion

2004; Thieme Medical Publishers (Germany); Volume: 36; Issue: 11/12 Linguagem: Inglês

10.1055/s-2004-826159

1439-4286

P. Dubé, P. L. Brubaker,

Apelin-related biomedical research

The intestinal glucagon-like peptides, GLP-1 and GLP-2, are important regulators of nutrient intake, digestion, absorption and metabolism. Extensive studies have shown that the co-secretion of GLP-1 and GLP-2 is regulated by a variety of dietary nutrient, neural and endocrine inputs. Furthermore, secretion of these peptides is altered in a number of pathological conditions, including type 2 diabetes and obesity. The purpose of this review is to discuss the regulation of GLP-1 and GLP-2 secretion in both health and disease.