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Innovations in phenotyping of mouse models in the German Mouse Clinic

2012; Springer Science+Business Media; Volume: 23; Issue: 9-10 Linguagem: Inglês

10.1007/s00335-012-9415-1

1432-1777

Helmut Fuchs, Valérie Gailus‐Durner, Susanne Neschen, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar‐Pimentel, Lore Becker, Alexander Bohla, Julia Calzada‐Wack, Christian M. Cohrs, Anna Dewert, Barbara Fridrich, Lillian Garrett, Lisa Glasl, Alexander Götz, Wolfgang Hans, Sabine M. Hölter, Marion Horsch, Anja Hurt, Eva Janas, Dirk Janik, Melanie Kahle, Martin Kistler, Tanja Klein‐Rodewald, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Gabriele Möller, Beatrix Naton, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Michael Räß, Birgit Rathkolb, Jan Rozman, Markus F. Scheerer, Evelyn Schiller, Anja Schrewe, Ralph Steinkamp, Claudia Stöger, Minxuan Sun, Wilfried Szymczak, Irina Treise, Ingrid Liliana Vargas Panesso, Alexandra Vernaleken, Monja Willershäuser, Annemarie Wolff-Muscate, Ramona Zeh, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Oliver Eickelberg, Jack Favor, Jochen Graw, Heinz Höfler, Christoph Höschen, Hugo A. Katus, Martin Klingenspor, Thomas Klopstock, Frauke Neff, Markus Ollert, Holger Schulz, Tobias Stöger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Martin Hrabé de Angelis,

Gene Regulatory Network Analysis

Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("top-down projects"). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).