H 2 S: A Universal Defense Against Antibiotics in Bacteria
2011; American Association for the Advancement of Science; Volume: 334; Issue: 6058 Linguagem: Inglês
10.1126/science.1209855
ISSN1095-9203
AutoresKonstantin Shatalin, Elena Shatalina, А. С. Миронов, Evgeny Nudler,
Tópico(s)Enzyme function and inhibition
ResumoMany prokaryotic species generate hydrogen sulfide (H(2)S) in their natural environments. However, the biochemistry and physiological role of this gas in nonsulfur bacteria remain largely unknown. Here we demonstrate that inactivation of putative cystathionine β-synthase, cystathionine γ-lyase, or 3-mercaptopyruvate sulfurtransferase in Bacillus anthracis, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli suppresses H(2)S production, rendering these pathogens highly sensitive to a multitude of antibiotics. Exogenous H(2)S suppresses this effect. Moreover, in bacteria that normally produce H(2)S and nitric oxide, these two gases act synergistically to sustain growth. The mechanism of gas-mediated antibiotic resistance relies on mitigation of oxidative stress imposed by antibiotics.
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