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362. Evaluation the Effects of MIP-1a on Ex Vivo Expansion of Cord Blood Hematopoietic Progenitor Cells in Different Culture Media

2006; Elsevier BV; Volume: 13; Linguagem: Inglês

10.1016/j.ymthe.2006.08.420

1525-0024

Kamran Alimoghaddam, Mitra Khalili, Massoud Soleimani, Moezi Lili, P Ghodsi, A Arjmand, Ardeshir Ghavamzadeh,

Mesenchymal stem cell research

Introduction:The use of ex vivo expansion of hematopoietic progenitor cells has been suggested as a possible means to accelerate the speed of engraftment in cord blood (CB) transplantation. Macrophage inflammatory protein-1 alpha (MIP-1a) has been shown to have a role in the control of myeloid stem and progenitor cell proliferation. So the aim of this study was to evaluate the effects of MIP-1a on ex vivo expansion of hematopoietic progenitor cells in different culture media for the propose of cord blood transplantation or gene therapy.