Overlapping Protective and Destructive Regulatory Pathways in Apical Periodontitis
2013; Elsevier BV; Volume: 40; Issue: 2 Linguagem: Inglês
10.1016/j.joen.2013.10.036
ISSN1878-3554
Autores Tópico(s)Bone Metabolism and Diseases
ResumoIntroduction Protective and destructive immunoreactions take place simultaneously in apical periodontitis. However, the same reactions defending the periapical area from infection-derived damage may also result in host tissue injury. Methods The inflammatory reaction of the periapical tissues is self-limited. Regeneration of the injured tooth-supporting structures may follow elimination of the causative microbial irritation. Results Recent experimental and clinical observations have identified important interplay between positive and negative regulatory pathways. A network of stimulatory and inhibitory feedback loops may influence the intensity of the defense and inflammatory responses and the balance between bone resorption and regeneration, resulting in lesion expansion or healing of apical periodontitis. Conclusions We critically discuss research data on regulatory mechanisms that control the activity of host effector cells and signaling molecules during interactions with pathogenic microbes.
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