ErbB-4: mechanism of action and biology
2003; Elsevier BV; Volume: 284; Issue: 1 Linguagem: Inglês
10.1016/s0014-4827(02)00100-3
ISSN1090-2422
Autores Tópico(s)Cell Adhesion Molecules Research
ResumoThe most recently described member of the ErbB receptor tyrosine kinase family is ErbB-4. In general, the structure of this receptor and its mechanism of action is similar to that described for ErbB-1. However, significantly less is known about ErbB-4 and there are several novel aspects to its structure, mechanism of action, and biology. This includes the spectrum of ligands that activate ErbB-4, the presence of functionally distinct isoforms, a proteolytic processing pathway to the nucleus, and the capacity to induce a spectrum of cellular responses such as mitogenesis, differentiation, growth inhibition, and survival.
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