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Square‐Wave Voltammetry as Analytical Tool for Real‐Time Study of Controlled Naproxen Releasing from Cellulose Derivative Materials

2015; Wiley; Volume: 27; Issue: 8 Linguagem: Inglês

10.1002/elan.201500011

1521-4109

Wilson T. Fonseca, Rodrigo Santos, Janainne Nunes Alves, Sabrina Dias Ribeiro, Regina M. Takeuchi, André L. Santos, Rosana Maria Nascimento de Assunção, Guimes Rodrigues Filho, Rodrigo A.A. Muñoz,

Electrochemical sensors and biosensors

Abstract This work reports the successful use of square‐wave voltammetry (SWV) to directly assess the controlled releasing profile of naproxen from lab‐made cellulose derivative materials (membranes and microparticles) in phosphate buffer (pH 7.4) at 36 °C. Particular advantage of SWV refers to the direct real‐time monitoring of released drug from cellulose derivative microparticles, which cannot be easily assessed by UV‐spectrophotometry. Moreover, SWV was able to detect modifications in the naproxen releasing profile due to morphology and processing of membranes and microparticles. The possible miniaturization and versatility of SWV suggest the promising application on the study of several drug delivery systems, including in vivo studies.