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Increased frequency of the long (S) allotype of CR1 (the C3b/C4b receptor, CD35) in patients with systemic lupus erythematosus

1992; Oxford University Press; Volume: 89; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2249.1992.tb06871.x

1365-2249

Pascale Cornillet, Philippe Gredy, J.L. Pennaforte, Olivier Meyer, M Kazatchkine, J. Cohen,

Chronic Lymphocytic Leukemia Research

SUMMARY The allotypic forms of the C3b/C4b receptor (CR1, CD35) differ in length, in the number of expressed C3b binding sites and thus in their ability to mediate the processing of circulating C3- and C4-bearing immune complexes. We have used a combination of three informative restriction fragment length polymorphisms (RFLPs) to assess the frequencies of the F (most frequent allele comprised of four long homologous repeats (LHR)), S (five LHR) and F′ (three LHR) alleles of the C3b/C4b receptor (CR1, CD35) in a French population of patients with systemic lupus erythematosus (SLE) (n= 63) and healthy controls (n= 158). A significantly higher frequency of the S phenotype was observed among patients (51%) as compared with controls (26%). The F′allele was found in 2/61 patients and 1/85 healthy controls, indicating the rare occurrence of the short CR1 allele in SLE. This allele is also extremely rare in the normal population. The overrepresentation of the S long allele among patients is indicative of a genetic linkage between CR1 and susceptibility to SLE.