EEG, EMG and behavioral evidence for the involvement of endorphin systems in postictal events after electroconvulsive shock in rats
1982; Elsevier BV; Volume: 31; Issue: 9 Linguagem: Inglês
10.1016/0024-3205(82)90544-6
ISSN1879-0631
AutoresFrank C. Tortella, Alan Cowan,
Tópico(s)Pharmacological Receptor Mechanisms and Effects
ResumoWe studied the effects of transauricular electroshock (ECS) on EEG and EMG patterns, and overt behaviors (wet-dog shaking and excessive grooming), caused by RX 336-M (7,8-dihydro-5', 6'-dimethylcyclohex-5'-eno-1-1', 2', 8',14 codeinone) in rats. Male, Sprague Dawley rats were prepared with cerebrocortical EEG and temporalis muscle EMG electrodes. In sham-shocked rats, RX 336-M (6 mg/kg, i.p.) induced behavioral activation, rapid forepaw movements, wet-dog shaking and exessive grooming; this sydrome was associated with EEG activation and EMG spiking. ECS alone produced a generalized seizure followed by postictal EEG slowing and behavioral depression. ECS suppressed the RX 336-M-induced behavioral syndrome and associated EEG and EMG responses. This attenuating action of ECS, presumed to involve the release of endogenous opioids, was antagonized when the rats were pretreated with naloxone (10 mg/kg, s.c.). Our results provide further evidence for the view that endogenous opioids are involved in the pathophysiology of certain postictal phenomena.
Referência(s)