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An improved oxadiazole synthesis using peptide coupling reagents

1996; Elsevier BV; Volume: 37; Issue: 37 Linguagem: Inglês

10.1016/s0040-4039(96)01492-x

1873-3581

Gui‐Bai Liang, Feng Danqing,

Synthesis and biological activity

Substituted 1,2,4-oxadiazoles were synthesized in good yields in a one pot procedure by condensation of the corresponding amidoxime with carboxylic acids in the presence of a peptide coupling reagent in diglyme, followed by heating the reaction mixture to 100°C for several hours.