Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups
2009; Beilstein Institute for the Advancement of Chemical Sciences; Volume: 5; Linguagem: Inglês
10.3762/bjoc.5.56
ISSN2195-951X
AutoresJulien Rolland, Xacobe C. Cambeiro, Carles Rodríguez‐Escrich, Miquel À. Pericàs,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoA continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.
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