Antimutagenicity, cytotoxicity and composition of chlorophyllin copper complex
1997; Elsevier BV; Volume: 120; Issue: 2 Linguagem: Inglês
10.1016/s0304-3835(97)00304-2
ISSN1872-7980
AutoresSimon Chernomorsky, Raymond C. Rancourt, Kamalpreet Virdi, Alvin B. Segelman, R. D. Poretz,
Tópico(s)Porphyrin Metabolism and Disorders
ResumoThe preparation of chlorophyllin copper complex (CCC), shown to be a tumor promoter in an animal model (Nelson, R.L. (1992) Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737–740), also inhibits the activities of direct- and indirect-acting mutagens in the Salmonella assay and exhibits cytostatic and cytocidal effects toward myeloma cells. Data from elemental analyses, spectrophotometry and reversed-phase high-performance liquid chromatography indicate that CCC preparations generally used in antimutagenic/anticarcinogenic experiments are variable, complex mixtures of structurally distinct porphyrins lacking copper in some instances. This variability of the composition may be a cause for the differences reported for the tumor promotion activity of CCC.
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