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Evaluation of the Physical Properties of Compressed Tablets I

1965; Elsevier BV; Volume: 54; Issue: 9 Linguagem: Inglês

10.1002/jps.2600540926

1520-6017

J. A. Seitz, Gerald M. Flessland,

Pharmacology and Obesity Treatment

Studies were conducted to evaluate what changes occurred in the physical properties of compressed tablets as the operation of a rotary tableting machine was varied. Thin large-diameter tablets showed a capping tendency that was not apparent in smaller-diameter or thicker tablets. The crushing strength of tablets stored at 71 per cent R.H. for 28days was unchanged, but the tablets became more friable. Increasing the compressional speed reduced the crushing strength and increased the capping tendency, but did not affect the friability of compressed tablets. At the higher compressional rates, the tablets showed a greater elastic response than at the slower speeds. Compressing the tablets at various depths in the die had no affect on the physical properties of the compressed tablets.