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A novel formulation of albendazole solution: oral bioavailability and efficacy evaluation

1997; Elsevier BV; Volume: 156; Issue: 2 Linguagem: Inglês

10.1016/s0378-5173(97)00204-4

1873-3476

Susana Torrado, Mario Lopez, Guillermo Torrado, F. Bolás‐Fernández, Santiago Torrado, R Cadórniga,

Parasites and Host Interactions

To improve the oral bioavailability of albendazole, a poorly water-soluble drug, a new liquid formulation was investigated in mice. The liquid formulation studied was a solvent system of Transcutol® (40% w/w) in 1.2 pH buffer. A significant (p<0.05) increased relative bioavailability was obtained with this albendazole solution as compared with an albendazole suspension. A Trichinella/mouse model was used to evaluate the efficacy of the formulation against the different stages of the parasite. The higher concentration–time plasma profile of the albendazole solution would explain the greater therapeutic effect obtained with this new formulation against the systemic phases of the Trichinella model studied. This albendazole solution presented an efficacy against the migrating larvae phase twice that of the albendazole suspension. The efficacy of the solution (95.5%) in the encysted phase was significantly (p<0.05) higher than the efficacy obtained with the albendazole suspension (2.4%).