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Did the Four Human Cancer Cell Lines DLD-1, HCT-15, HCT-8, and HRT-18 Originate from One and the Same Patient?

1998; Elsevier BV; Volume: 107; Issue: 1 Linguagem: Inglês

10.1016/s0165-4608(98)00081-8

1873-4456

Stefan Vermeulen, T.R. Chen, Frank Speleman, Friedel Nollet, Frans van Roy, Marc Mareel,

Cancer Cells and Metastasis

Four human colon cancer cell lines, HCT-8, HRT-18, DLD-1, and HCT-15, with an epithelioid morphotype reproducibly formed α-catenin-deficient round cells. Using DNA fingerprinting, we found that these four cell lines have an identical genetic background. Our finding strongly suggests a genetic background for the reproducible loss of α-catenin and the ensuing acquisition of invasiveness in all four cell lines.