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FeLV-FAIDS-induced immunodeficiency syndrome in cats

1989; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês

10.1016/0165-2427(89)90127-x

1873-2534

James I. Mullins, Edward A. Hoover, Julie Overbaugh, Sandra L. Quackenbush, P R Donahue, Mary Poss,

Animal Disease Management and Epidemiology

Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).